Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017813 | 1.00 | CHEK1 (0.33) | CHEK1KCNH2DYRK1ALMNAMAPT | |
| SCHEMBL4023100 | 1.00 | CHEK1 (0.33) | CHEK1KCNH2DYRK1ALMNAMAPT | |
| SCHEMBL4019355 | 0.86 | PTGDR2 (0.35) | LMNAMAPTKDM4ERAB9ATSHR | |
| SCHEMBL4017815 | 0.84 | CHEK1 (0.50) | CHEK1KCNH2DYRK1ALMNAMAPT | |
| SCHEMBL5132256 | 0.81 | CHEK1 (0.33) | CHEK1RAB9AGPR119 | |
| SCHEMBL5128333 | 0.77 | PTGDR2 (0.35) | LMNAMAPTKDM4ERAB9ATSHR | |
| SCHEMBL5132632 | 0.74 | CHEK1 (0.46) | CHEK1KCNH2DYRK1ALMNAHSD17B10 | |
| SCHEMBL5129516 | 0.71 | CNR2 (0.41) | DYRK1A | |
| SCHEMBL4005010 | 0.71 | DYRK1A (0.46) | DYRK1A | |
| SCHEMBL6508712 | 0.66 | ATR (0.36) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
| EP-1976523-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007081572-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | CHEK1 1/4885KCNH2 2921/4885DYRK1A 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.