Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128333 | 0.91 | PTGDR2 (0.35) | PTGDR2CYP2D6BRD4HTR2CSLC6A4 | |
| SCHEMBL4023100 | 0.86 | CHEK1 (0.33) | RAB9ALMNAMAPTTSHRKDM4E | |
| SCHEMBL4014749 | 0.86 | CHEK1 (0.33) | RAB9ALMNAMAPTTSHRKDM4E | |
| SCHEMBL4017813 | 0.86 | CHEK1 (0.33) | RAB9ALMNAMAPTTSHRKDM4E | |
| SCHEMBL5129516 | 0.86 | CNR2 (0.41) | PTGDR2CYP2D6BRD4GNRHRKMT2A | |
| SCHEMBL4017815 | 0.80 | CHEK1 (0.50) | RAB9ALMNAMAPTKDM4E | |
| SCHEMBL14192084 | 0.74 | PRMT5 (0.34) | PTGDR2MAPTPDE5APOLBKMT2A | |
| SCHEMBL5128346 | 0.74 | CHEK1 (0.41) | PTGDR2SMN1; SMN2PDE4APDE4BPDE4C | |
| SCHEMBL5132632 | 0.70 | CHEK1 (0.46) | CYP2D6LMNASMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL4018879 | 0.65 | CHEK1 (0.51) | PTGDR2HTR2CLMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-7550477-B2 | Inhibitors of checkpoint kinases | MERCK & CO., INC. (US) | 2009-06-23 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | MERCK SHARP & DOHME CORP. | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023767-A1 | Inhibitors of Checkpoint Kinases | CHEK1, CHEK2, BUB1B | PTGDR2 4316/4885CYP2D6 4516/4885BRD4 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.