Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ILK | Q13418 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13974933 | 0.79 | MAPT (0.62) | POLBGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL692697 | 0.72 | ILK (0.30) | ILK | |
| SCHEMBL29041058 | 0.70 | MEN1 (0.50) | POLBGAACYP1A2ILKMAPT | |
| SCHEMBL4164612 | 0.69 | POLB (0.46) | POLBGAAILKMAPTRAB9A | |
| SCHEMBL13860530 | 0.69 | MAPT (0.57) | POLBGAAMAPTRAB9AMEN1 | |
| SCHEMBL16200220 | 0.68 | MAPK1 (0.48) | POLBGAACYP1A2ILKMAPT | |
| SCHEMBL16200211 | 0.68 | MEN1 (0.48) | POLBGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1270330 | 0.67 | NPC1 (0.51) | POLBMAPTRAB9AMEN1KMT2A | |
| SCHEMBL1075673 | 0.67 | CYP1A2 (0.53) | POLBGAACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4163853 | 0.66 | POLB (0.41) | POLBGAAILKMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044063-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008001070-A1 | PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-01-03 | — | — | WO | disclosed |