SCHEMBL401645

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL402059	0.93	PDE5A (0.61)	PDE5AKDM4ERECQLMMP13HCAR3
	SCHEMBL399659	0.91	PDE5A (0.59)	PDE5AKDM4ERECQLMMP13CSNK2A1
	SCHEMBL406149	0.91	PDE5A (0.59)	PDE5AKDM4ERECQLMMP13CSNK2A2
	SCHEMBL403714	0.90	PDE5A (0.69)	PDE5AKDM4ERECQLMMP13CSNK2A1
	SCHEMBL404509	0.89	PDE5A (0.57)	PDE5AKDM4ERECQLMMP13CSNK2A2
	SCHEMBL400954	0.89	PDE5A (0.68)	PDE5AKDM4ERECQLMMP13CSNK2A2
	SCHEMBL403999	0.88	PDE5A (0.63)	PDE5AKDM4ERECQLKMT2APOLB
	SCHEMBL402247	0.87	PDE5A (0.78)	PDE5AKDM4ERECQLCSNK2A2CSNK2A1
	SCHEMBL17888978	0.86	MMP13 (0.58)	PDE5AMMP13KMT2AUSP2
	SCHEMBL403481	0.86	PDE5A (0.76)	PDE5AKDM4ERECQLCSNK2A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.