Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.47 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.47 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.47 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.47 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.47 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.47 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.47 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.47 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401645 | 0.86 | PDE5A (0.72) | MMP13PDE5AKMT2AUSP2 | |
| SCHEMBL17888986 | 0.86 | PDE5A (0.72) | MMP13PDE5AKMT2ATUBB4ATUBB | |
| SCHEMBL17888980 | 0.85 | POLB (0.50) | MMP13PDE5AKMT2APARP14USP2 | |
| SCHEMBL13367923 | 0.85 | MMP13 (0.53) | MMP13PDE5AKMT2APARP14GRIN1 | |
| SCHEMBL399659 | 0.83 | PDE5A (0.59) | MMP13PDE5AKMT2APARP14 | |
| SCHEMBL17888979 | 0.82 | ALDH1A1 (0.50) | MMP13PDE5AKMT2APARP14 | |
| SCHEMBL17888985 | 0.81 | POLB (0.52) | MMP13TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL402059 | 0.81 | PDE5A (0.61) | MMP13PDE5AKMT2AGRIN1GRIN2B | |
| SCHEMBL17888977 | 0.81 | RNASEH1 (0.55) | PDE5AKMT2APARP14 | |
| SCHEMBL10054289 | 0.81 | KMT2A (0.50) | MMP13PDE5AKMT2ATUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050739-B1 | QUINAZOLINE DERIVATIVE | ASKA PHARM CO LTD (JP) | 2016-07-06 | — | — | EP | claimed |