Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27662974 | 0.84 | MAPT (0.34) | ALDH1A1TSHRHSD17B10MAPTDRD2 | |
| SCHEMBL4020863 | 0.79 | CCR1 (0.44) | ALDH1A1MAPTDRD2DRD3TDP1 | |
| SCHEMBL27662971 | 0.79 | ALDH1A1 (0.37) | ALDH1A1TSHRHSD17B10MAPTDRD2 | |
| SCHEMBL2876645 | 0.75 | CCR1 (0.48) | ALDH1A1HSD17B10MAPTPOLBHTT | |
| SCHEMBL4459923 | 0.74 | HSP90AA1 (0.40) | ALDH1A1MAPTDRD2DRD3TDP1 | |
| SCHEMBL6167745 | 0.70 | MEN1 (0.44) | ALDH1A1MAPTTDP1LMNAPOLB | |
| SCHEMBL4014716 | 0.70 | GFER (0.40) | ALDH1A1TSHRMAPTDRD2DRD3 | |
| SCHEMBL4304948 | 0.69 | MAPT (0.37) | ALDH1A1TSHRMAPTDRD2DRD3 | |
| SCHEMBL4016082 | 0.69 | DRD2 (0.38) | ALDH1A1MAPTDRD2DRD3TDP1 | |
| SCHEMBL4019239 | 0.69 | MEN1 (0.40) | ALDH1A1TSHRMAPTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |