Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778621 | 0.76 | MAPK8 (0.41) | CNR1CNR2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL16041735 | 0.75 | HCRTR2 (0.42) | CNR1CNR2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL12794738 | 0.75 | POLB (0.43) | CNR1CNR2KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL31214503 | 0.74 | HCRTR1 (0.40) | KDM4EDHODHL3MBTL1ALDH1A1 | |
| SCHEMBL1505151 | 0.72 | GRM4 (0.40) | CNR1CNR2KDM4E | |
| SCHEMBL28368341 | 0.70 | ALDH1A1 (0.50) | L3MBTL1ALDH1A1GAA | |
| SCHEMBL10699924 | 0.68 | ALDH1A1 (0.45) | L3MBTL1ALDH1A1 | |
| SCHEMBL17611245 | 0.68 | NAPRT (0.46) | CNR1CNR2KDM4EASPHKDM8 | |
| SCHEMBL14991796 | 0.67 | TACR1 (0.37) | KDM4EASPHKDM8TACR1L3MBTL1 | |
| SCHEMBL26598055 | 0.67 | L3MBTL1 (0.34) | KDM4EASPHKDM8L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044050-A1 | NEW PYRIDINE ANALOGUES | Astra Zeneca AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008004946-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |