SCHEMBL4016729

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL15838779	0.92	SIRT2 (0.83)	SIRT2KDRKMT2AKDM4EMEN1
	SCHEMBL4017013	0.85	KMT2A (0.65)	SIRT2KDRKMT2AKDM4EMEN1
	SCHEMBL15838780	0.85	SIRT2 (0.75)	SIRT2KMT2AKDM4EMEN1MAPK1
	SCHEMBL15819262	0.83	SIRT2 (1.00)	SIRT2KMT2AKDM4EMEN1LMNA
	SCHEMBL15838778	0.82	SIRT2 (0.71)	SIRT2KMT2AKDM4EMEN1MAPK1
	SCHEMBL15953556	0.81	SIRT2 (0.70)	SIRT2KMT2AKDM4EMEN1MAPK1
	SCHEMBL4016992	0.77	APEX1 (0.58)	KMT2AKDM4EMEN1HPGDSMN1; SMN2
	SCHEMBL4017689	0.77	KDR (0.71)	KDRKMT2AKDM4EMAPK1NAMPT
	SCHEMBL4019386	0.76	KDR (1.00)	KDRKMT2AMEN1MAPK1NAMPT
	SCHEMBL4019971	0.76	KDR (0.78)	KDRKMT2AKDM4EMEN1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.