Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PER2 | O15055 | 1/20 | 0.38 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.38 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11748273 | 0.83 | TP53 (0.42) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL11321199 | 0.79 | TP53 (0.44) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL9314947 | 0.77 | TP53 (0.49) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL7959682 | 0.77 | MAPT (0.46) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL9081406 | 0.77 | TP53 (0.46) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL8388252 | 0.76 | TP53 (0.48) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL186732 | 0.76 | TP53 (0.48) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL9360403 | 0.76 | TP53 (0.46) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL6845542 | 0.75 | TP53 (0.47) | MAPTTP53GLAALDH1A1HPGD | |
| SCHEMBL1802310 | 0.75 | TP53 (0.45) | MAPTTP53GLAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8187831-B2 | Chimeric proteins, nucleic acids encoding chimeric proteins, methods and kits for assaying for sodium ions and for lithium ions in a sample, using inter alia, a 3'(2'),5'-bisphosphate nucleotidase | GENERAL ATOMICS (US) | 2012-05-29 | — | — | US | disclosed |
| EP-1677665-A4 | DETERMINATION OF IONS USING ION-SENSITIVE ENZYMES | GEN ATOMICS (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1677665-A2 | DETERMINATION OF IONS USING ION-SENSITIVE ENZYMES | GENERAL ATOMICS (US) | 2006-07-12 | — | — | EP | disclosed |
| US-20050142606-A1 | Determination of ions using ion-sensitive enzymes | DIAZYME LABORATORIES, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2005027725-A2 | DETERMINATION OF IONS USING ION-SENSITIVE ENZYMES | GENERAL ATOMICS (US) | 2005-03-31 | — | — | WO | disclosed |
| EP-0533183-B1 | Composition for the measurement of potassium ion concentration | TOYO BOSEKI (JP) | 1997-12-29 | — | — | EP | disclosed |
| US-5334507-A | Pyruvate kinase, glycerol kinase, glycerol-3-phosphate oxidase, peroxidase, reduced chromogen, adenosine diphosphate, phosphoenolpyruvic acid | TOYO BOSEKI KABUSHIKI KAISHA (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0533183-A2 | Composition for the measurement of potassium ion concentration | TOYO BOSEKI KABUSHIKI KAISHA Trading under the name of Toyobo Co., Ltd. (JP) | 1993-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050142606-A1 | Determination of ions using ion-sensitive enzymes | ITPA, NT5E, NT5C2 | MAPT 3923/4885TP53 2169/4885GLA 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.