Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890287 | 0.89 | PPARG (0.53) | PPARGAGTR1AGTR2 | |
| SCHEMBL4016963 | 0.87 | AGTR1 (0.39) | PPARGAGTR1AGTR2KMT2A | |
| SCHEMBL4016260 | 0.77 | PPARG (0.52) | PPARGAGTR1 | |
| SCHEMBL1895054 | 0.75 | AGTR1 (0.55) | PPARGAGTR1 | |
| SCHEMBL1891957 | 0.74 | AGTR1 (0.54) | PPARGAGTR1 | |
| SCHEMBL12349180 | 0.74 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL1893260 | 0.74 | PPARG (0.51) | PPARGAGTR1AGTR2 | |
| SCHEMBL1893323 | 0.74 | PPARG (0.58) | PPARGAGTR1AGTR2 | |
| SCHEMBL4164574 | 0.73 | PPARG (0.60) | PPARGAGTR1AGTR2 | |
| SCHEMBL1892153 | 0.73 | PPARG (0.46) | MAPK14PPARGAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074117-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008062905-A2 | HETEROMONOCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-29 | — | — | WO | disclosed |