Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.56 |
| ▸ | SUV39H1 | O43463 | 2/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 9/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021867 | 0.95 | MAPT (0.58) | SMYD3SUV39H1PRMT1MAPTRAB9A | |
| SCHEMBL4019439 | 0.86 | MAPT (0.54) | SMYD3SUV39H1PRMT1MAPTRAB9A | |
| SCHEMBL4582882 | 0.81 | MAPT (0.59) | MAPTRAB9ADRD2HTR2ADRD3 | |
| SCHEMBL4024322 | 0.80 | MAPT (0.58) | MAPTRAB9APAK1DRD2HTR2A | |
| SCHEMBL4018090 | 0.80 | PDGFRB (0.60) | SMYD3SUV39H1PRMT1PAK1LMNA | |
| SCHEMBL2798904 | 0.77 | LMNA (0.71) | SMYD3SUV39H1PRMT1RAB9ALMNA | |
| SCHEMBL4017662 | 0.76 | SUV39H1 (0.48) | SMYD3SUV39H1PRMT1PAK1LMNA | |
| SCHEMBL4024042 | 0.72 | PAK1 (0.71) | PAK1LMNAHTTSMN1; SMN2DRD2 | |
| SCHEMBL4017146 | 0.71 | LMNA (0.40) | RAB9ALMNAHTTSMN1; SMN2AKT1 | |
| SCHEMBL9967045 | 0.71 | KIT (0.65) | PAK1AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |