Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | DTYMK | P23919 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29178118 | 0.82 | KDM4E (0.49) | TDP1L3MBTL1CA1CA2KDM4E | |
| SCHEMBL28055894 | 0.81 | TDP1 (0.47) | TDP1L3MBTL1CA1CA2KDM4E | |
| SCHEMBL12496332 | 0.81 | TDP1 (0.47) | TDP1L3MBTL1CA1CA2KDM4E | |
| SCHEMBL2475360 | 0.81 | L3MBTL1 (0.56) | TDP1L3MBTL1CA1CA2KDM4E | |
| SCHEMBL28577900 | 0.81 | KDM4E (0.48) | TDP1L3MBTL1CA1CA2KDM4E | |
| SCHEMBL927382 | 0.81 | TDP1 (0.47) | TDP1L3MBTL1CA1CA2KDM4E | |
| SCHEMBL10887981 | 0.77 | TDP1 (0.47) | TDP1L3MBTL1KDM4EMAPTMEN1 | |
| SCHEMBL3826317 | 0.76 | TDP1 (0.62) | TDP1L3MBTL1CA1CA2CASP6 | |
| SCHEMBL27971912 | 0.75 | KDM4E (0.49) | TDP1L3MBTL1KDM4EMAPTMEN1 | |
| SCHEMBL31481283 | 0.74 | TDP1 (0.50) | TDP1L3MBTL1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074123-A1 | NOVEL ANXIOLYTIC COMPOUNDS | Bionomics Limited (AU) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008046135-A1 | NOVEL ANXIOLYTIC COMPOUNDS | BIONOMICS LIMITED (AU) | 2008-04-24 | — | — | WO | disclosed |