Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28560223 | 0.85 | TDP1 (0.42) | L3MBTL1TDP1TSHRPOLBKDM4E | |
| SCHEMBL4017164 | 0.81 | TDP1 (0.49) | L3MBTL1TDP1POLBCA1CA2 | |
| SCHEMBL29178118 | 0.81 | KDM4E (0.49) | L3MBTL1TDP1TSHRPOLBCA1 | |
| SCHEMBL5481728 | 0.80 | MAPT (0.48) | POLBCA1CA2KDM4EALDH1A1 | |
| SCHEMBL28055894 | 0.79 | TDP1 (0.47) | L3MBTL1TDP1TSHRPOLBCA1 | |
| SCHEMBL28577900 | 0.79 | KDM4E (0.48) | L3MBTL1TDP1TSHRPOLBCA1 | |
| SCHEMBL927382 | 0.79 | TDP1 (0.47) | L3MBTL1TDP1TSHRPOLBCA1 | |
| SCHEMBL12496332 | 0.79 | TDP1 (0.47) | L3MBTL1TDP1POLBCA1CA2 | |
| SCHEMBL1121873 | 0.77 | GPR35 (0.50) | L3MBTL1TDP1POLBCASP6KDM4E | |
| SCHEMBL1245681 | 0.76 | TSHR (0.51) | L3MBTL1TDP1TSHRPOLBCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130190309-A1 | PHTHALAZINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. | 2013-07-25 | — | — | US | disclosed |
| CN-102317284-A | Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases | SIRTRIS PHARMACEUTICALS INC | 2012-01-11 | — | — | CN | disclosed |
| CN-102307871-A | Isoindolinone and related analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-01-04 | — | — | CN | disclosed |
| EP-2373646-A1 | PHTHALAZINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2011-10-12 | — | — | EP | disclosed |
| WO-2010077947-A1 | PHTHALAZINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190309-A1 | PHTHALAZINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | L3MBTL1 3339/4885TDP1 1672/4885TSHR 2800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.