Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SUV39H1 | O43463 | 2/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 8/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017880 | 0.88 | ALDH1A1 (0.41) | CCNE1CDK2 | |
| SCHEMBL4021963 | 0.81 | CYP1A2 (0.49) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4017646 | 0.80 | GRM5 (0.53) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4017654 | 0.80 | SMYD3 (0.55) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4024378 | 0.79 | CYP1A2 (0.57) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4016242 | 0.78 | CCNE1 (0.51) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4023998 | 0.77 | CYP1A2 (0.53) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4022823 | 0.76 | CYP1A2 (0.53) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4021891 | 0.75 | SUV39H1 (0.52) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 | |
| SCHEMBL4019432 | 0.74 | CNR1 (0.57) | CYP1A2CYP2D6SUV39H1PRMT1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066654-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | Bayer Schering Pharma AG (DE) | 2009-06-10 | — | — | EP | claimed |
| WO-2008028691-A1 | N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-03-13 | — | — | WO | claimed |