Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | GRK2 | P25098 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | LOX | P28300 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10372094 | 0.79 | CA2 (1.00) | CA2LOX | |
| SCHEMBL4012060 | 0.78 | CYP3A4 (0.55) | POLBGRK2SMN1; SMN2TDP1MAPT | |
| SCHEMBL3202432 | 0.75 | MAPT (0.51) | POLBGRK2SMN1; SMN2TDP1MAPT | |
| Sulfuric Acid SCHEMBL10850211 | 0.73 | CA2 (0.88) | CA2LOX | |
| SCHEMBL3116490 | 0.73 | TSHR (0.44) | POLBGRK2SMN1; SMN2TDP1MAPT | |
| SCHEMBL6695141 | 0.73 | SMN1; SMN2 (0.53) | POLBGRK2SMN1; SMN2TDP1MAPT | |
| SCHEMBL6988820 | 0.72 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2MAPTRAB9AKMT2A | |
| SCHEMBL6983808 | 0.72 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2MAPTRAB9AKMT2A | |
| SCHEMBL1348410 | 0.70 | APOBEC3G (0.50) | SMN1; SMN2MAPTKMT2AHPGDLMNA | |
| SCHEMBL1163936 | 0.70 | SMN1; SMN2 (0.66) | POLBSMN1; SMN2MAPTCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |