Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | DDO | Q99489 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KHK | P50053 | 1/20 | 0.49 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30556309 | 1.00 | DAO (0.55) | DAOBRD4DDOKDRCHEK1 | |
| SCHEMBL31620114 | 0.82 | KDR (0.57) | DAOBRD4DDOKDRCHEK1 | |
| SCHEMBL31048730 | 0.81 | BRD4 (0.59) | DAOBRD4DDOKDRCHEK1 | |
| SCHEMBL837270 | 0.81 | BRD4 (0.59) | DAOBRD4DDOKDRCHEK1 | |
| SCHEMBL24427742 | 0.77 | DAO (0.58) | DAODDOMAPTMEN1KMT2A | |
| SCHEMBL30806289 | 0.77 | HCAR1 (0.44) | DAOKDRCHEK1HPGDPDGFRB | |
| SCHEMBL25912343 | 0.77 | DAO (0.58) | DAODDOMAPTMEN1KMT2A | |
| SCHEMBL29370120 | 0.75 | DAO (0.60) | DAOBRD4DDOKDRCHEK1 | |
| SCHEMBL10481645 | 0.75 | DAO (0.60) | DAOBRD4DDOKDRCHEK1 | |
| SCHEMBL10617 | 0.75 | DAO (0.60) | DAOBRD4DDOKDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3503891-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | Bristol-Myers Squibb Company (US) | 2019-07-03 | — | — | EP | claimed |
| WO-2018039512-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-01 | — | — | WO | claimed |
| CN-114014805-A | Preparation method of trifluoromethylated 2, 4-quinolinedione compounds | 南宁师范大学 | 2022-02-08 | — | — | CN | disclosed |
| EP-3830080-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | Merck Patent GmbH (DE) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020025517-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-02-06 | — | — | WO | disclosed |
| CN-108503582-B | Microwave-assisted synthesis method of 2- (1H) -quinolinone compounds | 湖南科技学院 | 2020-01-07 | — | — | CN | disclosed |
| CN-106459126-B | Novel grape sugar derivatives and the cell imaging method and imaging agent for using the derivative | 国立大学法人弘前大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-108503582-A | The microwave assisted synthesizing method of 2- (1H)-quinolinones compound | 湖南科技学院 | 2018-09-07 | — | — | CN | disclosed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |
| EP-0707569-A1 | 4-AMINO-2-QUINOLINONE DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995000488-A1 | 4-AMINO-2-QUINOLINONE DERIVATIVES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 1995-01-05 | — | — | WO | disclosed |