Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 14/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.55 |
| ▸ | RXRA | P19793 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017261 | 0.87 | NR1H2 (0.58) | NR1H2NR1H3RXRACYP2C9PTGDR2 | |
| SCHEMBL4011501 | 0.86 | NR1H2 (0.55) | NR1H2NR1H3RXRACYP2C9SLC40A1 | |
| SCHEMBL4012639 | 0.86 | NR1H2 (0.72) | NR1H2NR1H3RXRACYP2C9PTGDR2 | |
| SCHEMBL4011996 | 0.84 | NR1H2 (0.66) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4012181 | 0.81 | PTGDR2 (0.45) | NR1H2NR1H3RXRAPTGDR2SLC40A1 | |
| SCHEMBL4012339 | 0.81 | NR1H2 (0.49) | NR1H2NR1H3RXRAPTGDR2 | |
| SCHEMBL4012775 | 0.80 | NR1H2 (0.77) | NR1H2NR1H3RXRACYP2C9 | |
| SCHEMBL4011482 | 0.80 | NR1H2 (0.47) | NR1H2NR1H3RXRAPTGDR2SLC40A1 | |
| SCHEMBL27786951 | 0.77 | NR1H2 (0.46) | NR1H2NR1H3RXRACYP2C9PTGDR2 | |
| SCHEMBL4012778 | 0.77 | NR1H2 (0.56) | NR1H2NR1H3RXRAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | claimed |
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |