Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.43 |
| ▸ | COMT | P21964 | 4/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.39 |
| ▸ | MMP14 | P50281 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299566 | 0.85 | NR1H2 (0.50) | PTGDR2NR1H2NR1H3COMTPIK3CD | |
| SCHEMBL4011482 | 0.83 | NR1H2 (0.47) | PTGDR2NR1H2NR1H3PDE4DMEN1 | |
| SCHEMBL4011946 | 0.82 | NR4A2 (0.49) | PTGDR2NR1H2NR1H3PDE4DMMP14 | |
| SCHEMBL4018063 | 0.81 | NR1H2 (0.55) | PTGDR2NR1H2NR1H3SLC40A1RXRA | |
| SCHEMBL4018184 | 0.81 | PIK3CD (0.54) | PTGDR2NR1H2NR1H3PIK3CDRXRA | |
| SCHEMBL17044063 | 0.80 | KDR (0.46) | PTGDR2COMTMEN1HSP90AA1KMT2A | |
| SCHEMBL4011996 | 0.79 | NR1H2 (0.66) | PTGDR2NR1H2NR1H3RXRA | |
| SCHEMBL4012347 | 0.79 | NR1H3 (0.45) | PTGDR2NR1H2NR1H3PDE4DHTR1A | |
| SCHEMBL4012339 | 0.78 | NR1H2 (0.49) | PTGDR2NR1H2NR1H3PDE4DMEN1 | |
| SCHEMBL17044086 | 0.78 | RIPK2 (0.43) | PTGDR2COMTMEN1HSP90AA1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074098-A2 | QUINOLINE COMPOUNDS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008049047-A2 | QUINOLINE COMPOUNDS | WYETH (US) | 2008-04-24 | — | — | WO | disclosed |