Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13024308 | 0.78 | TSHR (0.49) | MAPK1TSHRALDH1A1KMT2ACYP2C19 | |
| SCHEMBL14566300 | 0.76 | TSHR (0.48) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL13024311 | 0.76 | MAPK1 (0.46) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL14139187 | 0.74 | MAPK1 (0.45) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL13024389 | 0.72 | KDM4E (0.63) | KDM4ENLRP3CYP2C19CCR1 | |
| SCHEMBL3466044 | 0.72 | CCR1 (0.46) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL3464564 | 0.72 | MAPK1 (0.43) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL26982613 | 0.72 | KDM4E (0.44) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL13024322 | 0.71 | ALDH1A1 (0.43) | MAPK1TSHRALDH1A1KMT2AKDM4E | |
| SCHEMBL13024312 | 0.70 | L3MBTL1 (0.42) | MAPK1TSHRALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |