Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP5 | P51878 | 2/20 | 0.45 |
| ▸ | CASP4 | P49662 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1526838 | 0.73 | CHKA (0.39) | CASP1CASP5CASP4HRH4HPGD | |
| SCHEMBL7303410 | 0.72 | CYP1A2 (0.40) | HRH4CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL15415674 | 0.72 | CYP1A2 (0.40) | HRH4CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL19548104 | 0.70 | SMN1; SMN2 (0.61) | CASP1CASP5CASP4HRH4CHRM3 | |
| SCHEMBL15415235 | 0.69 | CHKA (0.34) | HRH4CHRM3PDE4APDE4BPDE4C | |
| SCHEMBL9163278 | 0.68 | CASP1 (0.53) | CASP1CASP5CASP4HRH4CHRM3 | |
| SCHEMBL8962166 | 0.68 | CASP1 (0.77) | CASP1CASP5CASP4HRH4CHRM3 | |
| SCHEMBL1671129 | 0.68 | KMT2A (0.56) | HRH4HPGDSMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL24851478 | 0.67 | CHRM3 (0.55) | CASP1CASP5CASP4HRH4CHRM3 | |
| SCHEMBL6712680 | 0.67 | HRH1 (0.50) | CASP1CASP5CASP4SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054901-A1 | Dihydrothiazine prodrugs of thiazolium agents | SYNVISTA THERAPEUTICS, INC. | 2007-03-08 | — | — | US | claimed |
| EP-1622885-A2 | DIHYDROTHIAZINE PRODRUGS OF THIAZOLIUM AGENTS | ALTEON, INC. (US) | 2006-02-08 | — | — | EP | claimed |
| US-20050014747-A1 | Dihydrothiazine prodrugs of thiazolium agents | ALTEON INC. | 2005-01-20 | — | — | US | claimed |
| WO-2004094396-A2 | DIHYDROTHIAZINE PRODRUGS OF THIAZOLIUM AGENTS | ALTEON, INC. (US) | 2004-11-04 | — | — | WO | claimed |
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | claimed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | claimed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | claimed |
| US-7511036-B2 | Dihydrothiazine prodrugs of thiazolium agents | SYNVISTA THERAPEUTICS, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20070054901-A1 | Dihydrothiazine prodrugs of thiazolium agents | SYNVISTA THERAPEUTICS, INC. | 2007-03-08 | — | — | US | disclosed |
| EP-1622885-A2 | DIHYDROTHIAZINE PRODRUGS OF THIAZOLIUM AGENTS | ALTEON, INC. (US) | 2006-02-08 | — | — | EP | disclosed |
| US-20050014747-A1 | Dihydrothiazine prodrugs of thiazolium agents | ALTEON INC. | 2005-01-20 | — | — | US | disclosed |
| WO-2004094396-A2 | DIHYDROTHIAZINE PRODRUGS OF THIAZOLIUM AGENTS | ALTEON, INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| EP-0589985-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1994-04-06 | — | — | EP | disclosed |
| WO-1993000342-A1 | 2-AMINO-4-ARYL-THIAZOLES WITH ANTIASTHMATIC AND ANTI-INFLAMMATORY ACTIVITIES ON THE RESPIRATORY TRACT | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1993-01-07 | — | — | WO | disclosed |
| EP-0519449-A1 | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract | BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) | 1992-12-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014747-A1 | Dihydrothiazine prodrugs of thiazolium agents | DHPS, HRH4, CYP8B1 | CASP1 1008/4885CASP5 1229/4885CASP4 1747/4885 |
| US-20070054901-A1 | Dihydrothiazine prodrugs of thiazolium agents | DHPS, HRH4, CYP8B1 | CASP1 1008/4885CASP5 1229/4885CASP4 1747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.