⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28024649 | 0.97 | — | — | |
| SCHEMBL1502438 | 0.91 | — | — | |
| SCHEMBL132364 | 0.84 | TSHR (0.67) | — | |
| SCHEMBL2154814 | 0.81 | TSHR (0.72) | — | |
| SCHEMBL7329781 | 0.81 | TSHR (0.72) | — | |
| SCHEMBL494288 | 0.81 | TSHR (0.72) | — | |
| Hydrochloric Acid SCHEMBL7947881 | 0.81 | TSHR (0.63) | — | |
| SCHEMBL495310 | 0.81 | TSHR (0.72) | — | |
| SCHEMBL2154041 | 0.81 | TSHR (0.72) | — | |
| SCHEMBL466419 | 0.81 | TSHR (0.72) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103159670-A | Synthetic method of apixaban intermediate 1-(4-nitrobenzophenone)-2-piperidone | LANZHOU CHEM PHYS INST | 2013-06-19 | — | — | CN | claimed |
| US-20090264648-A1 | SYNTHESIS OF PYRAZOLES | WYETH (US) | 2009-10-22 | — | — | US | claimed |
| WO-2009091832-A1 | SYNTHESIS OF PYRAZOLES | WYETH (US) | 2009-07-23 | — | — | WO | claimed |
| EP-3212620-B1 | PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF | JUBILANT GENERICS LTD FORMERLY JUBILANT LIFE SCIENCES DIVISION (IN) | 2020-11-25 | — | — | EP | disclosed |
| EP-3212620-B1 | PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF | JUBILANT GENERICS LTD FORMERLY JUBILANT LIFE SCIENCES DIVISION (IN) | 2020-11-25 | — | — | EP | disclosed |
| US-9932336-B2 | Process for the preparation of apixaban and intermediates thereof | Jubilant Generics Limited (IN) | 2018-04-03 | — | — | US | disclosed |
| US-20170313699-A1 | PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF | Jubilant Generics Limited (IN) | 2017-11-02 | — | — | US | disclosed |
| EP-3212620-A1 | PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF | Jubilant Generics Limited (Formerly Jubilant Life Sciences Division) (IN) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016067308-A1 | PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF | JUBILANT GENERICS LIMITED (FORMERLY JUBILANT LIFE SCIENCES DIVISION) (IN) | 2016-05-06 | — | — | WO | disclosed |
| CN-104892601-A | Preparation method of antithrombotic drug Apixaban | JIANGSU ZHONGBANG PHARMACEUTICAL CO LTD | 2015-09-09 | — | — | CN | disclosed |
| CN-104262338-A | Synthetic method of apixaban and intermediate thereof | ZHEJIANG TIANYU PHARMACY CO LTD | 2015-01-07 | — | — | CN | disclosed |
| EP-0669329-B1 | Difluorprostacyclins, intermediates for production thereof and processes for production thereof | ASAHI GLASS CO LTD (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5747531-A | STABILITY; ANTICOAGULANTS, VASODILATORS | ASAHI GLASS COMPANY LTD. (JP) | 1998-05-05 | — | — | US | disclosed |
| EP-0789022-A1 | Difluoroprostacyclins, intermediates for production thereof and process for production | ASAHI GLASS COMPANY LTD. (JP) | 1997-08-13 | — | — | EP | disclosed |
| US-5616732-A | Intermediates for difluoroprostacyclins and methods for their production | ASAHI GLASS COMPANY LTD. (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0734386-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | Abbott Laboratories (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5538995-A | Difluoroprostacyclins | ASAHI GLASS COMPANY LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5486525-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0669329-A1 | Difluorprostacyclins, intermediates for production thereof and processes for production thereof | ASAHI GLASS COMPANY LTD. (JP) | 1995-08-30 | — | — | EP | disclosed |
| WO-1995016687-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LABORATORIES (US) | 1995-06-22 | — | — | WO | disclosed |