Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HHAT | Q5VTY9 | 4/20 | 0.47 |
| ▸ | LHCGR | P22888 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1499097 | 0.99 | HHAT (0.48) | HHATLHCGRNPSR1MAPK1KDM4E | |
| SCHEMBL4018143 | 0.99 | HHAT (0.48) | HHATLHCGRNPSR1MAPK1KDM4E | |
| SCHEMBL5439863 | 0.99 | HHAT (0.48) | HHATLHCGRNPSR1MAPK1KDM4E | |
| Hydrochloric Acid SCHEMBL5239130 | 0.98 | HHAT (0.47) | HHATLHCGRNPSR1MAPK1KDM4E | |
| SCHEMBL24419940 | 0.85 | HHAT (0.52) | HHATLHCGR | |
| SCHEMBL2307868 | 0.85 | HHAT (0.48) | HHATLHCGRNPSR1MAPK1DRD1 | |
| SCHEMBL4738266 | 0.85 | HHAT (0.48) | HHATLHCGRNPSR1MAPK1DRD1 | |
| SCHEMBL2916838 | 0.82 | HDAC8 (0.42) | NPSR1KDM4EDRD1 | |
| Sulfuric Acid SCHEMBL2306919 | 0.82 | HHAT (0.45) | HHATLHCGRDRD1 | |
| Bromide SCHEMBL5236979 | 0.78 | KDM4E (0.46) | NPSR1KDM4EDRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121704-A2 | POLYMORPHIC FORMS OF CLOPIDOGREL HYDROBROMIDE | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2009-11-25 | — | — | EP | disclosed |
| EP-2121704-A2 | POLYMORPHIC FORMS OF CLOPIDOGREL HYDROBROMIDE | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008108742-A3 | POLYMORPHIC FORMS OF CLOPIDOGREL HYDROBROMIDE | KRKA TOVARNA ZDRAVIL D D NOVO (SI) | 2009-05-14 | — | — | WO | disclosed |
| WO-2008108742-A2 | POLYMORPHIC FORMS OF CLOPIDOGREL HYDROBROMIDE | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008108742-A2 | POLYMORPHIC FORMS OF CLOPIDOGREL HYDROBROMIDE | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2008-09-12 | — | — | WO | disclosed |