SCHEMBL4018143

SCHEMBL4018143

O=C(O)CN1CCc2sccc2C1c1ccccc1Cl

nearest known ligand 0.60

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HHAT Q5VTY9 4/20 0.48
LHCGR P22888 4/20 0.46
NPSR1 Q6W5P4 2/20 0.45
MAPK1 P28482 1/20 0.45
KDM4E B2RXH2 1/20 0.44
DRD1 P21728 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1499097 1.00 HHAT (0.48) HHATLHCGRNPSR1MAPK1KDM4E
SCHEMBL5439863 1.00 HHAT (0.48) HHATLHCGRNPSR1MAPK1KDM4E
Hydrochloric Acid SCHEMBL5239130 0.99 HHAT (0.47) HHATLHCGRNPSR1MAPK1KDM4E
Bromide SCHEMBL4019730 0.99 HHAT (0.47) HHATLHCGRNPSR1MAPK1KDM4E
SCHEMBL24419940 0.86 HHAT (0.52) HHATLHCGR
SCHEMBL2307868 0.86 HHAT (0.48) HHATLHCGRNPSR1MAPK1DRD1
SCHEMBL4738266 0.86 HHAT (0.48) HHATLHCGRNPSR1MAPK1DRD1
SCHEMBL2916838 0.83 HDAC8 (0.42) NPSR1KDM4EDRD1
Sulfuric Acid SCHEMBL2306919 0.82 HHAT (0.45) HHATLHCGRDRD1
SCHEMBL5769463 0.79 HHAT (0.38) HHATLHCGRNPSR1MAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006042481-A1 METHOD OF OBTAINING CLOPIDOGREL ZENTIVA A.S. (CZ) 2006-04-27 WO claimed
US-20060074242-A1 Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I USV LIMITED (IN) 2006-04-06 US claimed
US-20090187022-A1 Crystalline clopidogrel hydrobromide and processes for preparation thereof TEVA PHARMACEUTICALS USA, INC. FOR BARBADOS. 2009-07-23 US disclosed
EP-2078025-A2 PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, tovarna zdravil, d.d., Novo mesto (SI) 2009-07-15 EP disclosed
EP-1907397-A4 METHOD OF PREPARING CLOPIDOGREL AND INTERMEDIATES USED THEREIN HANMI PHARM IND CO LTD (KR) 2009-05-27 EP disclosed
EP-1907397-A1 METHOD OF PREPARING CLOPIDOGREL AND INTERMEDIATES USED THEREIN Hanmi Pharm. Co., Ltd. (KR) 2008-04-09 EP disclosed
WO-2008034912-A2 PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) 2008-03-27 WO disclosed
WO-2006137628-A1 METHOD OF PREPARING CLOPIDOGREL AND INTERMEDIATES USED THEREIN HANMI PHARM. CO., LTD. (KR) 2006-12-28 WO disclosed
WO-2006042481-A1 METHOD OF OBTAINING CLOPIDOGREL ZENTIVA A.S. (CZ) 2006-04-27 WO disclosed
EP-1606231-A1 PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS Nadkarni, Sunil Sadanand (IN) 2005-12-21 EP disclosed
WO-2004074215-A1 PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS NADKARNI SUNIL SADANAND (IN) 2004-09-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060074242-A1 Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I SRR, P2RY11, CYP2C19 HHAT 3926/4885LHCGR 2959/4885NPSR1 212/4885
US-20090187022-A1 Crystalline clopidogrel hydrobromide and processes for preparation thereof NUDT1, CYP2C9, PFKP HHAT 2285/4885LHCGR 1304/4885NPSR1 1135/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.