Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | CA9 | Q16790 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | IDO1 | P14902 | 2/20 | 0.58 |
| ▸ | MAOA | P21397 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 2/20 | 0.58 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.53 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11746910 | 0.98 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| Methane SCHEMBL2796518 | 0.98 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| Methane SCHEMBL8530831 | 0.98 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL159163 | 0.94 | NPC1 (0.76) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL525787 | 0.86 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL28883056 | 0.85 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL9176170 | 0.84 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL156779 | 0.82 | KMT2A (0.66) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL6524477 | 0.81 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL160341 | 0.80 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940787-A4 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INST MEDICAL RES (US) | 2009-07-01 | — | — | EP | claimed |
| EP-1940787-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | Lankenau Institute for Medical Research (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007050963-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2007-05-03 | — | — | WO | claimed |