SCHEMBL4020654

SCHEMBL4020654

Cc1cc(CS)cc(C(C)(C)C)c1O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 4/20 0.57
CYP2C19 P33261 4/20 0.57
CYP1A2 P05177 3/20 0.57
ALDH1A1 P00352 8/20 0.47
TSHR P16473 3/20 0.47
LMNA P02545 2/20 0.47
GAA P10253 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
CA2 P00918 2/20 0.47
POLB P06746 1/20 0.47
TYR P14679 1/20 0.47
HIF1A Q16665 4/20 0.46
MAPK1 P28482 3/20 0.46
MEN1 O00255 2/20 0.46
CYP3A4 P08684 2/20 0.46
BLM P54132 2/20 0.46
KMT2A Q03164 2/20 0.46
ATM Q13315 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
GMNN O75496 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5353910 0.88 ALDH1A1 (0.59) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL39353 0.84 CYP2C9 (0.61) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL8854338 0.84 CYP1A2 (0.61) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL29357192 0.84 CYP2C9 (0.61) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL30008257 0.84 CYP1A2 (0.61) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL8553511 0.82 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL362006 0.82 HSPA5 (0.65) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL31193211 0.82 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL1785592 0.82 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR
SCHEMBL9413678 0.82 CYP2C9 (0.59) CYP2C9CYP2C19CYP1A2ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103946352-B Functional fluids containing glycerol 雪佛龙奥伦耐有限责任公司 2018-05-18 CN disclosed
CN-107849476-A Purposes of the polyglycerol ester as the friction modifier in lubricant formulation agent 赢创油品添加剂有限公司 2018-03-27 CN disclosed
CN-107805532-A Functionalized olefin copolymers and lubricant oil composite with monoamine end capped polyether 雪佛龙奥伦耐有限责任公司 2018-03-16 CN disclosed
CN-107001970-A Refrigerator oil and working fluid composition for refrigerating machine JXTG能源株式会社 2017-08-01 CN disclosed
CN-104487556-B Lubricant composition for internal combustion engine 吉坤日矿日石能源株式会社 2017-03-15 CN disclosed
CN-106459817-A Lubricating oils 禾大公司 2017-02-22 CN disclosed
CN-103946353-B Diesel engine oil 雪佛龙奥伦耐有限责任公司 2017-02-15 CN disclosed
CN-106255683-A Dialkyl carbonates, methods of making and using the same 亨斯迈石油化学有限责任公司 2016-12-21 CN disclosed
CN-105683342-A Lubricant composition comprising hydroxycarboxylic acid derived friction modifier 禾大公司 2016-06-15 CN disclosed
CN-105555929-A Gear oil composition CRODA INT PLC 2016-05-04 CN disclosed
US-5043372-A Light stabilizers for polyolefins; reacting hydrazine with bis(half ester-half amide) ATOCHEM NORTH AMERICA, INC. (US) 1991-08-27 US disclosed
EP-0434079-A1 N,N'-hydrocarbylenebis(N-hals-substituted amic acid hydrazides) and their derivatives ELF ATOCHEM NORTH AMERICA, INC. (US) 1991-06-26 EP disclosed
EP-0214932-B1 LUBRICANT COMPOSITIONS AND HYDRAULIC FLUIDS COMPRISING SULFURIZED PHENOL DERIVATIVES, AND SULFURIZED PHENOL DERIVATIVES CIBA-GEIGY AG (CH) 1988-09-28 EP disclosed
US-4772405-A ANTIWEAR, EXTREME PRESSURE AND ANTIOXIDANT ADDITIVE FOR SYNTHETIC AND MINERAL LUBRICANTS, ELASTOMERS, HYDRAULIC FLUIDS CIBA-GEIGY CORPORATION (US) 1988-09-20 US disclosed
EP-0145658-B1 AMIDES OF HYDROXYPHENYLALKYLTHIO-ALKANE-CARBOXYLIC ACIDS CIBA-GEIGY AG (CH) 1987-07-08 EP disclosed
EP-0214932-A1 Lubricant compositions and hydraulic fluids comprising sulfurized phenol derivatives, and sulfurized phenol derivatives CIBA-GEIGY AG (CH) 1987-03-18 EP disclosed
EP-0140298-B1 SUBSTITUTED 4-HYDROXYBENZYLTHIOALDEHYDES AND KETONES CIBA-GEIGY AG (CH) 1987-01-28 EP disclosed
US-4618440-A FOR POLYMERS AND LUBRICATING OILS CIBA-GEIGY CORPORATION (US) 1986-10-21 US disclosed
EP-0145658-A1 Amides of hydroxyphenylalkylthio-alkane-carboxylic acids CIBA-GEIGY AG (CH) 1985-06-19 EP disclosed
EP-0140298-A1 Substituted 4-hydroxybenzylthioaldehydes and ketones CIBA-GEIGY AG (CH) 1985-05-08 EP disclosed