Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13347367 | 0.78 | GRIK1 (0.47) | CPA1GRIK1GRIK2CYP2C19ENPEP | |
| SCHEMBL31636 | 0.76 | GRIK1 (0.48) | CPA1GRIK1GRIK2CYP2C19ABCC4 | |
| SCHEMBL10824781 | 0.76 | TSHR (0.50) | GRIK1GRIK2CYP2C19ENPEPABCC4 | |
| Lithium SCHEMBL31299623 | 0.74 | GRIK1 (0.46) | CPA1GRIK1GRIK2CYP2C19ABCC4 | |
| Ammonia Solution, Strong SCHEMBL6396419 | 0.74 | GRIK1 (0.46) | CPA1GRIK1GRIK2CYP2C19ABCC4 | |
| Potassium SCHEMBL31299609 | 0.74 | GRIK1 (0.46) | CPA1GRIK1GRIK2CYP2C19ABCC4 | |
| SCHEMBL31299617 | 0.74 | GRIK1 (0.46) | CPA1GRIK1GRIK2CYP2C19ABCC4 | |
| Acetic Acid SCHEMBL1879600 | 0.73 | CHRM1 (0.39) | CPA1GRIK1GRIK2CYP2C19SLC6A3 | |
| SCHEMBL28123 | 0.72 | ENPEP (0.55) | GRIK1GRIK2ENPEPSLC6A3TSHR | |
| SCHEMBL5862560 | 0.72 | ABCC4 (0.46) | CPA1GRIK1GRIK2CYP2C19ENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2109604-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-10-21 | — | — | EP | disclosed |
| US-7544679-B2 | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-09 | — | — | US | disclosed |
| WO-2008092786-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-07 | — | — | WO | disclosed |
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-08-07 | — | — | US | disclosed |
| EP-1251122-A1 | Process for the preparation of epsilon-Caprolactam | DSM N.V. (NL) | 2002-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188463-A1 | 6-OXO-6,7-DIHYDRO-5H-DIBENZO[B,D]AZEPIN-7-YL DERIVATIVES | BACE1, BACE2, APH1B | CPA1 1428/4885GRIK1 1249/4885GRIK2 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.