Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR | Q13258 | 6/20 | 0.45 |
| ▸ | CCR1 | P32246 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817807 | 0.88 | CCR1 (0.44) | PTGDRCCR1ALDH1A1MAPTLMNA | |
| SCHEMBL4016355 | 0.82 | CCR1 (0.45) | PTGDRCCR1ALDH1A1TSHRMAPT | |
| SCHEMBL27764778 | 0.81 | PTGDR (0.46) | PTGDRCCR1ALDH1A1TSHRMAPT | |
| SCHEMBL4021713 | 0.78 | NOTUM (0.40) | ALDH1A1MAPTLMNAHTT | |
| SCHEMBL4014671 | 0.78 | NOTUM (0.40) | ALDH1A1MAPTLMNAHTT | |
| SCHEMBL13184085 | 0.76 | CCR1 (0.52) | PTGDRCCR1ALDH1A1TSHRMAPT | |
| SCHEMBL3464912 | 0.75 | CCR1 (0.51) | PTGDRCCR1ALDH1A1TSHRMAPT | |
| SCHEMBL3464913 | 0.75 | CCR1 (0.51) | PTGDRCCR1ALDH1A1TSHRMAPT | |
| SCHEMBL4323120 | 0.75 | CCR1 (0.38) | PTGDRCCR1NPSR1 | |
| SCHEMBL13428956 | 0.72 | BCL2A1 (0.47) | PTGDRCCR1ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |