Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4014671 | 1.00 | NOTUM (0.40) | NOTUMSLC6A9SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19003591 | 0.81 | SLC6A9 (0.43) | NOTUMSLC6A9SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL17897288 | 0.81 | SLC6A9 (0.43) | NOTUMSLC6A9SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3817807 | 0.80 | CCR1 (0.44) | MAPTLMNAALDH1A1 | |
| SCHEMBL4013778 | 0.74 | HTR3E (0.46) | SMN1; SMN2KMT2AMEN1POLBHPGD | |
| SCHEMBL15858055 | 0.72 | ADRA2A (0.52) | NOTUMCYP1A2CYP2D6GSK3BPOLB | |
| SCHEMBL17897287 | 0.72 | ADRA2A (0.52) | NOTUMCYP1A2CYP2D6GSK3BPOLB | |
| SCHEMBL6169684 | 0.72 | CCR1 (0.46) | — | |
| SCHEMBL6171097 | 0.72 | CCR1 (0.46) | — | |
| SCHEMBL18948533 | 0.69 | KMT2A (0.49) | NOTUMSLC6A9KMT2AMEN1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1691810-A4 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1691810-A1 | SUBSTITUTED PIPERAZINES | ChemoCentryx Inc (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005056015-A1 | SUBSTITUTED PIPERAZINES | CHEMOCENTRYX, INC. (US) | 2005-06-23 | — | — | WO | disclosed |