Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 7/20 | 0.32 |
| ▸ | CCND1 | P24385 | 4/20 | 0.32 |
| ▸ | CCND3 | P30281 | 4/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4021809 | 1.00 | MAPT (0.36) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL4031074 | 0.98 | MAPT (0.39) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL4031070 | 0.98 | MAPT (0.39) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL1448519 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL1448522 | 0.81 | ALDH1A1 (0.40) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL4025418 | 0.80 | HRH3 (0.36) | ALDH1A1MEN1KMT2ACDK4CCND1 | |
| SCHEMBL1447709 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL1447706 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAHTTMEN1 | |
| SCHEMBL4026141 | 0.78 | MAPK1 (0.35) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL4023024 | 0.78 | MAPT (0.32) | MAPTALDH1A1LMNAHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |