Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 5/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 4/20 | 0.33 |
| ▸ | CCND3 | P30281 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025418 | 0.97 | HRH3 (0.36) | MAPK1GAAJAK1MEN1KMT2A | |
| SCHEMBL4031074 | 0.80 | MAPT (0.39) | MEN1KMT2ACCND1CDK2CCNE1 | |
| SCHEMBL4031070 | 0.80 | MAPT (0.39) | MEN1KMT2ACCND1CDK2CCNE1 | |
| SCHEMBL4021809 | 0.78 | MAPT (0.36) | GAAMEN1KMT2ASMN1; SMN2CCND1 | |
| SCHEMBL4021806 | 0.78 | MAPT (0.36) | GAAMEN1KMT2ASMN1; SMN2CCND1 | |
| SCHEMBL1447759 | 0.76 | CDK2 (0.40) | GAAJAK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4243666 | 0.75 | GAA (0.41) | MAPK1GAAJAK1MEN1KMT2A | |
| SCHEMBL5102679 | 0.74 | ALOX15 (0.44) | MEN1KMT2ASMN1; SMN2CDK2HRH3 | |
| SCHEMBL4031026 | 0.73 | CDK2 (0.37) | GAAMEN1KMT2ACCND1CDK2 | |
| SCHEMBL5102686 | 0.71 | CDK2 (0.42) | MEN1KMT2ACDK2HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |