Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 13/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.72 |
| ▸ | CCR2 | P41597 | 1/20 | 0.72 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.72 |
| ▸ | BLM | P54132 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209327 | 0.93 | HPGD (0.70) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Hydrochloric Acid SCHEMBL27569479 | 0.91 | HPGD (0.68) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Hydrochloric Acid SCHEMBL27862467 | 0.91 | HPGD (0.68) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Bromide SCHEMBL10860157 | 0.91 | HPGD (0.68) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| SCHEMBL29823623 | 0.87 | CXCR4 (0.76) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Plerixafor SCHEMBL1649655 | 0.84 | CXCR4 (0.93) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| SCHEMBL29490414 | 0.84 | CXCR4 (1.00) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| SCHEMBL5611617 | 0.84 | CXCR4 (1.00) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| Plerixafor SCHEMBL19038 | 0.84 | CXCR4 (1.00) | CXCR4MEN1CHRM2CHRM1ADRA2C | |
| SCHEMBL3994683 | 0.83 | HRH3 (0.67) | CCR2TDP1HRH3HPGDCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616442-B1 | INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS INC (US) | 2018-08-08 | — | — | EP | disclosed |
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-05-25 | — | — | US | disclosed |
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-05-25 | — | — | US | disclosed |
| US-9562037-B2 | Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-02-07 | — | — | US | disclosed |
| US-9562037-B2 | Synthesis and use of amine-containing flavonoids as potent anti-leishmanial agents | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-02-07 | — | — | US | disclosed |
| US-20150239870-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2015-08-27 | — | — | US | disclosed |
| US-20150239870-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2015-08-27 | — | — | US | disclosed |
| EP-1082308-B1 | HETEROCYCLICALLY SUBSTITUTED AMIDES USED AS CALPAIN INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2009-04-01 | — | — | EP | disclosed |
| US-6686353-B1 | PREVENTING BLOOD MONOCYTES AND LYMPHOCYTES FROM INFILTRATING TISSUE | TEIJIN INTELLECTUAL PROPERTY CENTER LIMITED (JP) | 2004-02-03 | — | — | US | disclosed |
| US-6562827-B1 | For the treatment of diseases in which increased calpain activity occurs such as neurodegenerative diseases or neuronal damage are caused by ischemia, trauma or mass hemorrhages | ABBOTT LABORATORIES | 2003-05-13 | — | — | US | disclosed |
| EP-0914319-B1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LTD (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-1082308-A1 | HETEROCYCLICALLY SUBSTITUTED AMIDES USED AS CALPAIN INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999054305-A1 | HETEROCYCLICALLY SUBSTITUTED AMIDES USED AS CALPAIN INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-28 | — | — | WO | disclosed |
| EP-0914319-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997044329-A9 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | — | 1998-03-12 | — | — | WO | disclosed |
| WO-1997044329-A1 | DIARYLALKYL CYCLIC DIAMINE DERIVATIVES AS CHEMOKINE RECEPTOR ANTAGONISTS | TEIJIN LIMITED (JP) | 1997-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170143665-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | HNMT, TYR, PNMT | CXCR4 1228/4885MEN1 3283/4885CHRM2 2130/4885 |
| US-20150239870-A1 | SYNTHESIS AND USE OF AMINE-CONTAINING FLAVONOIDS AS POTENT ANTI-LEISHMANIAL AGENTS | HNMT, TYR, PNMT | CXCR4 1228/4885MEN1 3283/4885CHRM2 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.