SCHEMBL4022280

SCHEMBL4022280

Cc1ccc(-c2nocc2N(C(=O)O)C(C)c2ccccc2Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 8/20 0.41
CTSA P10619 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
LPAR2 Q9HBW0 1/20 0.35
LPAR3 Q9UBY5 1/20 0.35
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
KMT2A Q03164 1/20 0.34
FTO Q9C0B1 1/20 0.34
GPBAR1 Q8TDU6 2/20 0.34
AKR1C2 P52895 1/20 0.33
AKR1C1 Q04828 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
SMO Q99835 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4022910 0.90 LPAR1 (0.41) LPAR1CTSALPAR2LPAR3GPBAR1
SCHEMBL4021242 0.90 LPAR1 (0.41) LPAR1CTSASMN1; SMN2LPAR2LPAR3
SCHEMBL4022155 0.89 LPAR1 (0.47) LPAR1LPAR2LPAR3MEN1KMT2A
SCHEMBL4027626 0.88 LPAR1 (0.44) LPAR1LPAR2LPAR3MEN1KMT2A
SCHEMBL4027629 0.87 LPAR1 (0.39) LPAR1SMN1; SMN2NPC1RAB9AKMT2A
SCHEMBL4024811 0.87 LPAR1 (0.47) LPAR1LPAR2LPAR3MEN1KMT2A
SCHEMBL4027632 0.87 LPAR1 (0.39) LPAR1SMN1; SMN2NPC1RAB9AKMT2A
SCHEMBL4029400 0.80 ALDH1A1 (0.43) SMN1; SMN2MEN1KMT2AGPBAR1ALDH1A1
SCHEMBL4023164 0.77 LPAR1 (0.39) LPAR1SMN1; SMN2RAB9ALMNA
SCHEMBL4034159 0.76 LPAR1 (0.44) LPAR1CTSASMN1; SMN2LPAR2LPAR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7517996-B2 Azole compound AJINOMOTO CO., INC. (JP) 2009-04-14 US disclosed
US-20060194850-A1 Novel azole compound AJINOMOTO CO. INC (JP) 2006-08-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060194850-A1 Novel azole compound LPAR1, LPAR2, LPAR3 LPAR1 1/4885CTSA 1358/4885SMN1; SMN2 4589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.