Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029082 | 0.94 | GAA (0.45) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4028916 | 0.94 | GAA (0.45) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4034254 | 0.92 | KMT2A (0.44) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4033798 | 0.90 | MEN1 (0.43) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4033782 | 0.88 | MAPK1 (0.42) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4037102 | 0.86 | GPBAR1 (0.49) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4032705 | 0.85 | GPBAR1 (0.48) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4037046 | 0.85 | KMT2A (0.43) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4032656 | 0.83 | MEN1 (0.48) | ALDH1A1GAALMNAMAPTGPBAR1 | |
| SCHEMBL4037549 | 0.83 | NPSR1 (0.47) | ALDH1A1GAAGPBAR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1258484-B1 | NOVEL ISOXAZOLE AND THIAZOLE COMPOUNDS AND USE THEREOF AS DRUGS | KYOWA HAKKO KIRIN CO LTD (JP) | 2009-01-14 | — | — | EP | claimed |