Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 9/20 | 0.38 |
| ▸ | HTR2B | P41595 | 6/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488475 | 0.79 | TNF (0.36) | FAAHHTR2BTNFKDM4ENPC1 | |
| SCHEMBL3932067 | 0.73 | FAAH (0.58) | FAAHTNFGRM4 | |
| SCHEMBL4022293 | 0.72 | FAAH (0.69) | FAAHKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL2488473 | 0.68 | FAAH (0.43) | FAAHTNFKDM4ENPC1ALDH1A1 | |
| SCHEMBL4871345 | 0.67 | GRM4 (0.44) | FAAHTNFGRM4HTR2C | |
| SCHEMBL5793884 | 0.67 | GRM4 (0.39) | FAAHTNFKDM4ENPC1ALDH1A1 | |
| SCHEMBL24455072 | 0.64 | DYRK1A (0.49) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL29561930 | 0.64 | DYRK1A (0.49) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL2457512 | 0.59 | GRM4 (0.46) | FAAHTNFKDM4ENPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2458164 | 0.58 | GRM4 (0.46) | FAAHTNFKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009011904-A1 | COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2009-01-22 | — | — | WO | disclosed |