⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577556 | 0.75 | — | — | |
| Ethylene SCHEMBL154102 | 0.72 | ALDH1A1 (0.30) | — | |
| Charcoal, Activated SCHEMBL8437007 | 0.72 | ALDH1A1 (0.30) | — | |
| Bicarbonate SCHEMBL26925127 | 0.72 | CA1 (0.39) | — | |
| Methane SCHEMBL17726148 | 0.72 | ALDH1A1 (0.30) | — | |
| SCHEMBL4563364 | 0.71 | — | — | |
| Ethyne SCHEMBL23319710 | 0.69 | — | — | |
| SCHEMBL10704809 | 0.69 | ALDH1A1 (0.32) | — | |
| Lindane SCHEMBL2688197 | 0.69 | — | — | |
| Urea SCHEMBL10321479 | 0.67 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521439-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2009-04-21 | — | — | US | claimed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | claimed |
| US-7141559-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2006-11-28 | — | — | US | claimed |
| EP-1551860-B1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2006-11-22 | — | — | EP | claimed |
| US-7521439-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2009-04-21 | — | — | US | disclosed |
| US-20070027117-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | BISHOP RICHARD D | 2007-02-01 | — | — | US | disclosed |
| US-7141559-B2 | Glucocorticoid receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2006-11-28 | — | — | US | disclosed |
| EP-1551860-B1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| EP-1551860-A1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2005-07-13 | — | — | EP | disclosed |
| US-20040235810-A1 | Novel glucocorticoid receptor ligands for the treatment of metabolic disorders | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
| WO-2004000869-A1 | GLUCOCORTICOID RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2003-12-31 | — | — | WO | disclosed |