SCHEMBL4022543

SCHEMBL4022543

O=C1OC2(c3ccccc3Oc3cccc(Cl)c32)c2c(Cl)c(Cl)c(Cl)c(Cl)c21

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMAD3 P84022 2/20 0.48
ALDH1A1 P00352 5/20 0.43
RECQL P46063 3/20 0.43
TDP1 Q9NUW8 3/20 0.43
HPGD P15428 3/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
THRB P10828 2/20 0.43
BRCA1 P38398 2/20 0.43
HSD17B10 Q99714 2/20 0.43
BLM P54132 2/20 0.43
CYP3A4 P08684 2/20 0.43
TSHR P16473 2/20 0.43
MAPK1 P28482 1/20 0.43
CASP1 P29466 1/20 0.43
HIF1A Q16665 1/20 0.43
GLB1 P16278 1/20 0.43
CTRC Q99895 1/20 0.43
AHR P35869 3/20 0.38
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1608754 0.90 SMAD3 (0.46) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL6686737 0.82 AHR (0.36) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL9244110 0.80 AHR (0.44) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL9591308 0.77 SMAD3 (0.43) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL1607877 0.76 SMAD3 (0.58) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL11112647 0.76 FTO (0.43) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL6712128 0.76 MEN1 (0.48) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL3641991 0.75 HPGD (0.39) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL8429602 0.74 SMAD3 (0.42) SMAD3ALDH1A1RECQLTDP1HPGD
SCHEMBL1209657 0.74 FTO (0.43) SMAD3ALDH1A1RECQLTDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009097433-A1 NOVEL DYES AND USE THEREOF IN IMAGING MEMBERS AND METHODS ZINK IMAGING, INC. (US) 2009-08-06 WO disclosed