Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029984 | 0.83 | GFER (0.50) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL30523171 | 0.76 | MEN1 (0.74) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL2485234 | 0.76 | MAPT (0.61) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL4024926 | 0.76 | MEN1 (0.74) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL11735549 | 0.75 | MAPT (0.49) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL6688391 | 0.75 | MAPT (0.60) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL4025604 | 0.74 | MAPT (0.43) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL4726736 | 0.74 | MAPT (0.46) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL6688877 | 0.72 | MAPT (0.50) | MAPTTHRBMEN1KMT2ANPC1 | |
| SCHEMBL30571073 | 0.72 | MAPT (0.47) | MAPTTHRBMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |