Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029160 | 0.83 | GFER (0.47) | MAPTTHRBMEN1KMT2ALMNA | |
| SCHEMBL2486768 | 0.81 | KDM4E (0.49) | MAPTTHRBUSP2MEN1KMT2A | |
| SCHEMBL15067435 | 0.75 | KDM4E (0.52) | MAPTTHRBUSP2TP53KDM4E | |
| SCHEMBL30571073 | 0.75 | MAPT (0.47) | MAPTTHRBUSP2MEN1KMT2A | |
| SCHEMBL9623026 | 0.74 | USP2 (0.47) | MAPTTHRBUSP2MEN1KMT2A | |
| SCHEMBL4022771 | 0.74 | MAPT (0.48) | MAPTTHRBUSP2MEN1KMT2A | |
| SCHEMBL6922067 | 0.74 | USP2 (0.43) | MAPTTHRBUSP2LMNATP53 | |
| SCHEMBL5017970 | 0.72 | MAPT (0.42) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL6922902 | 0.71 | GAA (0.40) | MAPTUSP2MEN1KMT2ALMNA | |
| SCHEMBL6755332 | 0.71 | GFER (0.48) | MAPTMEN1KMT2ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |