Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CCND3 | P30281 | 2/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.34 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245094 | 0.93 | PTGS2 (0.38) | PTGS2MAPTALDH1A1PIK3CAMTOR | |
| SCHEMBL4245100 | 0.93 | PTGS2 (0.38) | PTGS2MAPTALDH1A1PIK3CAMTOR | |
| SCHEMBL4026915 | 0.86 | MAPT (0.38) | MAPTALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL4026913 | 0.86 | MAPT (0.38) | MAPTALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL1448519 | 0.84 | ALDH1A1 (0.40) | PTGS2MAPTALDH1A1CDK4CCND1 | |
| SCHEMBL1448522 | 0.84 | ALDH1A1 (0.40) | PTGS2MAPTALDH1A1CDK4CCND1 | |
| SCHEMBL1447709 | 0.84 | ALDH1A1 (0.43) | PTGS2MAPTALDH1A1CDK4CCND1 | |
| SCHEMBL1447706 | 0.84 | ALDH1A1 (0.43) | PTGS2MAPTALDH1A1CDK4CCND1 | |
| SCHEMBL4248909 | 0.83 | MAPT (0.45) | PTGS2MAPTALDH1A1CDK4CCND1 | |
| SCHEMBL4248915 | 0.83 | MAPT (0.45) | PTGS2MAPTALDH1A1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |