Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 8/20 | 0.42 |
| ▸ | BCHE | P06276 | 7/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SPR | P35270 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12426340 | 0.84 | ACHE (0.43) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL2202293 | 0.82 | SOS1 (0.44) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL15921330 | 0.78 | ACHE (0.40) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL6075309 | 0.73 | MAPT (0.47) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL12426347 | 0.71 | ACHE (0.44) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL14463345 | 0.70 | ACHE (0.46) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL6075269 | 0.70 | ACHE (0.43) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL4809314 | 0.69 | TP53 (0.46) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL5733680 | 0.69 | ACHE (0.40) | ACHEGRIN1GRIN2ABCHEALDH1A1 | |
| SCHEMBL18833249 | 0.69 | HTT (0.46) | ACHEGRIN1GRIN2ABCHERXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227407-B2 | Macrocyclic inhibitors of hepatitis C virus | MEDIVIR AB (SE) | 2012-07-24 | — | — | US | disclosed |
| US-20090062311-A1 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | JANSSEN SCIENCES IRELAND UC (IE) | 2009-03-05 | — | — | US | disclosed |
| EP-1912997-A1 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | Tibotec Pharmaceuticals Ltd. (IE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014925-A1 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062311-A1 | MACROCYLIC INHIBITORS OF HEPATITIS C VIRUS | HCCS, NR5A1, NR0B1 | ACHE 4832/4885GRIN1 677/4885GRIN2A 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.