Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023024 | 1.00 | MAPT (0.32) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL4523757 | 0.86 | CDK2 (0.37) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL1448317 | 0.86 | CDK2 (0.37) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL6621622 | 0.82 | CDK2 (0.35) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL6621616 | 0.82 | CDK2 (0.35) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL4022591 | 0.81 | CDK2 (0.36) | CDK2 | |
| SCHEMBL4031074 | 0.78 | MAPT (0.39) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL4031070 | 0.78 | MAPT (0.39) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL4021809 | 0.78 | MAPT (0.36) | MAPTALDH1A1HPGDCDK2TDP1 | |
| SCHEMBL4021806 | 0.78 | MAPT (0.36) | MAPTALDH1A1HPGDCDK2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485375-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-06-17 | — | — | EP | disclosed |