Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.47 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13963514 | 0.86 | PLA2G2A (0.58) | SMN1; SMN2PLA2G2APLA2G5TP53GAA | |
| SCHEMBL3225061 | 0.86 | PLA2G2A (0.58) | SMN1; SMN2PLA2G2APLA2G5TP53GAA | |
| SCHEMBL3355578 | 0.85 | HDAC8 (0.50) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB | |
| SCHEMBL17953989 | 0.85 | HSD17B10 (0.41) | POLBLMNAMAPTMAPK1HSD17B10 | |
| SCHEMBL2416451 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB | |
| SCHEMBL2416448 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB | |
| SCHEMBL11410186 | 0.83 | CYP1A2 (0.55) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB | |
| SCHEMBL14058740 | 0.81 | DPP8 (0.49) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB | |
| SCHEMBL14058739 | 0.81 | DPP8 (0.49) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB | |
| SCHEMBL11422020 | 0.79 | FOLH1 (0.44) | SMN1; SMN2PLA2G2APLA2G5ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009098451-A2 | BIOMARKERS OF AMINOPEPTIDASE INHIBITION | CHROMA THERAPEUTICS LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |