Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | AANAT | Q16613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272692 | 0.82 | MTNR1A (0.64) | MTNR1AALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL11189546 | 0.81 | MTNR1A (0.53) | MTNR1ALMNAHDAC1HDAC2HDAC6 | |
| SCHEMBL25139801 | 0.78 | GLS (0.48) | GLSALDH1A1KDM4EHPGDOPRM1 | |
| SCHEMBL10717270 | 0.77 | GLS (0.50) | GLSALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL13753750 | 0.77 | HDAC1 (0.63) | ALDH1A1HDAC1HDAC2HDAC3HDAC4 | |
| SCHEMBL16125637 | 0.77 | GLS (0.50) | GLSALDH1A1KDM4ELMNAOPRM1 | |
| SCHEMBL10242936 | 0.77 | PTPN1 (0.62) | ALDH1A1KDM4EHPGDSMN1; SMN2MEN1 | |
| SCHEMBL31750332 | 0.77 | GLS (0.50) | GLSALDH1A1KDM4ELMNAOPRM1 | |
| SCHEMBL4309213 | 0.76 | GRIN2D (0.54) | GLSALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL30009880 | 0.76 | GRIN2D (0.54) | GLSALDH1A1KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | claimed |
| EP-1478363-B1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LAB (US) | 2009-01-14 | — | — | EP | disclosed |