Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.76 |
| ▸ | HTR1A | P08908 | 4/20 | 0.76 |
| ▸ | HTR1D | P28221 | 3/20 | 0.76 |
| ▸ | HTR1B | P28222 | 3/20 | 0.76 |
| ▸ | HTR1F | P30939 | 3/20 | 0.76 |
| ▸ | HTR7 | P34969 | 3/20 | 0.76 |
| ▸ | DRD3 | P35462 | 3/20 | 0.76 |
| ▸ | DRD2 | P14416 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029770 | 0.90 | HTR6 (0.72) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL27642788 | 0.86 | HTR6 (0.76) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL739877 | 0.86 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL7245193 | 0.85 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL7439766 | 0.84 | HTR6 (0.85) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3622368 | 0.83 | HTR6 (0.67) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6926275 | 0.83 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4020191 | 0.83 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL16796502 | 0.83 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3624652 | 0.83 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (publ) (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003703-A1 | INDOLES AS 5-HT6 MODULATORS | BIOVITRUM AB (PUBL) (SE) | 2008-01-10 | — | — | WO | disclosed |