Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 20/20 | 0.85 |
| ▸ | HTR1A | P08908 | 2/20 | 0.85 |
| ▸ | HTR1D | P28221 | 2/20 | 0.85 |
| ▸ | HTR1B | P28222 | 2/20 | 0.85 |
| ▸ | HTR1F | P30939 | 2/20 | 0.85 |
| ▸ | HTR7 | P34969 | 2/20 | 0.85 |
| ▸ | DRD3 | P35462 | 2/20 | 0.85 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7443102 | 0.95 | HTR6 (0.77) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL739877 | 0.92 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Oxalic Acid SCHEMBL7433685 | 0.87 | HTR6 (0.90) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3611374 | 0.86 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Hydrochloric Acid SCHEMBL3624923 | 0.85 | HTR6 (0.78) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4023837 | 0.84 | HTR6 (0.76) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4020191 | 0.84 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL6926275 | 0.84 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Trifluoroacetic Acid SCHEMBL4019041 | 0.83 | HTR6 (0.82) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4029770 | 0.82 | HTR6 (0.72) | HTR6HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187805-B1 | TREATING CONDITION FOR WHICH SELECTIVE AGONISM OR ANTAGONISM OF 5-HT-6 RECEPTORS IS INDICATED BY ADMINISTERING COMPOUNDS SUCH AS N,N-DIMETHYL 2-(1-(BENZENESULPHONYL)-5-METHOXY-1H-INDOL-3-YL)ETHYLAMINE | MERCK SHARP & DOHME LTD. (GB) | 2001-02-13 | — | — | US | disclosed |