Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 15/20 | 0.53 |
| ▸ | CA2 | P00918 | 15/20 | 0.53 |
| ▸ | CA9 | Q16790 | 11/20 | 0.53 |
| ▸ | CA12 | O43570 | 8/20 | 0.44 |
| ▸ | CA7 | P43166 | 5/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024515 | 0.69 | CA2 (1.00) | CA1CA2CA9CA12CA7 | |
| SCHEMBL5288239 | 0.67 | CA1 (0.45) | CA1CA2CA9CA12CA7 | |
| SCHEMBL17824795 | 0.67 | CA1 (0.45) | CA1CA2CA9CA12CA7 | |
| SCHEMBL9810165 | 0.67 | CA1 (0.46) | CA1CA2CA9CA12CA7 | |
| SCHEMBL6297784 | 0.67 | CA2 (0.82) | CA1CA2CA9CA12CA7 | |
| SCHEMBL17350895 | 0.66 | CA1 (0.57) | CA1CA2CA9CA12CA7 | |
| SCHEMBL29902411 | 0.63 | MEN1 (0.63) | CA1CA2CA9CA12CA7 | |
| SCHEMBL27546526 | 0.62 | CA1 (0.60) | CA1CA2CA9CA12CA7 | |
| SCHEMBL17350894 | 0.62 | CA1 (0.48) | CA1CA2CA9CA12CA7 | |
| SCHEMBL8029327 | 0.62 | CA2 (0.76) | CA1CA2CA9CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968439-A2 | COMPOSITIONS USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | Synergy Pharmaceuticals Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014151200-A2 | COMPOSITIONS USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | SYNERGY PHARMACEUTICALS INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2009091813-A1 | COMPOUNDS USEFUL AS ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |