Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6880205 | 0.83 | HSD17B10 (0.52) | HSD17B10CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL20602364 | 0.80 | MAPT (0.59) | HSD17B10CYP1A2CYP2D6TSHRLMNA | |
| SCHEMBL4026285 | 0.80 | BAZ2B (0.49) | HSD17B10CYP1A2ALOX15LMNAUSP2 | |
| SCHEMBL17026942 | 0.79 | KDM4E (0.49) | HSD17B10HTR1DBAZ2BKDM4EMAPT | |
| SCHEMBL13657844 | 0.79 | KDR (0.48) | HSD17B10CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL5881040 | 0.79 | BAZ2B (0.53) | HSD17B10CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL4026759 | 0.78 | KMT2A (0.61) | HSD17B10ALOX15LMNATHRBKDM4E | |
| SCHEMBL6610802 | 0.78 | BAZ2B (0.52) | HSD17B10CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL4279959 | 0.78 | LMNA (0.67) | HSD17B10CYP1A2CYP2D6ALOX15TSHR | |
| SCHEMBL4286367 | 0.78 | LMNA (0.67) | HSD17B10CYP1A2CYP2D6ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |