Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27677995 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL15140009 | 0.81 | CYP1A1 (0.37) | SMN1; SMN2KDM4EMAPTALDH1A1CYP3A4 | |
| SCHEMBL29375470 | 0.80 | CA1 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL162625 | 0.80 | CA1 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7105911 | 0.79 | CA1 (0.42) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL15271433 | 0.78 | KMT2A (0.35) | SMN1; SMN2NFE2L2MAPK1KDM4EALDH1A1 | |
| Bromomethane SCHEMBL27848237 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL25434306 | 0.77 | CA1 (0.61) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL151213 | 0.77 | CA1 (0.61) | SMN1; SMN2CA12CA1CA2CA7 | |
| SCHEMBL27753904 | 0.77 | CA1 (0.61) | SMN1; SMN2CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | UNIVERSITY OF NEBRASKA - LINCOLN | 2015-01-29 | — | — | US | disclosed |
| US-8859614-B2 | Analogues of (−)-picropodophyllin, synthesis and uses thereof | University of Nebraska—Lincoln (US) | 2014-10-14 | — | — | US | disclosed |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2009-10-29 | — | — | US | disclosed |
| WO-2009100349-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-08-13 | — | — | WO | disclosed |
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031759-A1 | Analogues of (-)Picropodophyllin, Synthesis And Uses Thereof | PPOX, HCCS, DHPS | SMN1; SMN2 4538/4885CA12 4126/4885CA1 4193/4885 |
| US-20090271879-A1 | ANALOGUES OF (-)-PICROPODOPHYLLIN, SYNTHESIS AND USES THEREOF | PPOX, HCCS, DHPS | SMN1; SMN2 4480/4885CA12 4118/4885CA1 4149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.