Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 14/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NMBR | P28336 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039275 | 0.88 | CYP11B1 (0.41) | CYP11B1CYP11B2SIRT2ENPP2KMT2A | |
| SCHEMBL8803490 | 0.84 | CYP11B1 (0.43) | CYP11B1CYP11B2SIRT2ENPP2KMT2A | |
| SCHEMBL21193061 | 0.84 | SIRT2 (0.35) | CYP11B1CYP11B2SIRT2ENPP2KMT2A | |
| SCHEMBL9587793 | 0.81 | CYP11B1 (0.41) | CYP11B1CYP11B2SIRT2ENPP2KMT2A | |
| SCHEMBL5060964 | 0.81 | LMNA (0.40) | CYP11B1CYP11B2SIRT2ENPP2 | |
| SCHEMBL5474675 | 0.81 | SIRT2 (0.40) | CYP11B1CYP11B2SIRT2ENPP2NMBR | |
| SCHEMBL12887208 | 0.81 | CYP11B1 (0.41) | CYP11B1CYP11B2SIRT2ENPP2KMT2A | |
| SCHEMBL6363934 | 0.80 | SIRT2 (0.38) | CYP11B1CYP11B2SIRT2ENPP2NMBR | |
| SCHEMBL2202154 | 0.80 | CYP11B1 (0.40) | CYP11B1CYP11B2SIRT2ENPP2 | |
| SCHEMBL7453723 | 0.79 | CYP11B1 (0.39) | CYP11B1CYP11B2SIRT2ENPP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1222174-B1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA PHARMACEUTICAL (JP) | 2009-05-27 | — | — | EP | disclosed |
| US-6649643-B1 | Antitumor, anticarcinogenic, and antimetastasis agents; benign prostatic hyperplasia, alopecia, endometriosis, uterine myoma, hirsutism, virilism, precocious puberty, mastopathy, and polycystic overay syndrome treatment | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-11-18 | — | — | US | disclosed |
| EP-1222174-A1 | IMIDAZOL-4-YLMETHANOLS USED AS INHIBITORS OF STEROID C17-20 LYASE | Takeda Chemical Industries, Ltd. (JP) | 2002-07-17 | — | — | EP | disclosed |
| WO-2001030762-A1 | IMIDAZOL-4-YLMETHANOLS USE AS INHIBITORS OF STEROID C17-20 LYASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-03 | — | — | WO | disclosed |