Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 8/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4023755 | 0.92 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CBALDH1A1HPGD | |
| SCHEMBL243814 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL244427 | 0.80 | SCD (0.40) | PIK3CDPIK3CAPIK3CBALDH1A1TSHR | |
| SCHEMBL31741937 | 0.76 | SMN1; SMN2 (0.34) | ALDH1A1TSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL241170 | 0.75 | ALDH1A1 (0.55) | ALDH1A1HPGDTSHRSMN1; SMN2KDM4E | |
| SCHEMBL13787617 | 0.74 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBALDH1A1HPGD | |
| SCHEMBL16432263 | 0.74 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CBALDH1A1HPGD | |
| SCHEMBL16404868 | 0.73 | PIK3CD (0.72) | PIK3CDPIK3CAPIK3CBALDH1A1HPGD | |
| SCHEMBL30712341 | 0.72 | SMN1; SMN2 (0.35) | TSHRSMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL243883 | 0.72 | SCD (0.53) | PIK3CDPIK3CAPIK3CBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054408-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | Novartis Ag (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |